Evaluation of a non-prime site substituent and warheads combined with a decahydroisoquinolin scaffold as a SARS 3CL protease inhibitor.
Identifieur interne : 000B45 ( Main/Exploration ); précédent : 000B44; suivant : 000B46Evaluation of a non-prime site substituent and warheads combined with a decahydroisoquinolin scaffold as a SARS 3CL protease inhibitor.
Auteurs : Kouji Ohnishi [Japon] ; Yasunao Hattori [Japon] ; Kazuya Kobayashi [Japon] ; Kenichi Akaji [Japon]Source :
- Bioorganic & medicinal chemistry [ 1464-3391 ] ; 2019.
Descripteurs français
- KwdFr :
- Antiviraux (), Antiviraux (pharmacologie), Antiviraux (synthèse chimique), Cysteine endopeptidases (), Domaine catalytique, Inhibiteurs de la cystéine protéinase (), Inhibiteurs de la cystéine protéinase (pharmacologie), Inhibiteurs de la cystéine protéinase (synthèse chimique), Isoquinoléines (), Isoquinoléines (pharmacologie), Isoquinoléines (synthèse chimique), Protéines virales (), Protéines virales (antagonistes et inhibiteurs), Simulation de docking moléculaire, Structure moléculaire, Virus du SRAS (enzymologie).
- MESH :
- antagonistes et inhibiteurs : Protéines virales.
- enzymologie : Virus du SRAS.
- pharmacologie : Antiviraux, Inhibiteurs de la cystéine protéinase, Isoquinoléines.
- synthèse chimique : Antiviraux, Inhibiteurs de la cystéine protéinase, Isoquinoléines.
- Antiviraux, Cysteine endopeptidases, Domaine catalytique, Inhibiteurs de la cystéine protéinase, Isoquinoléines, Protéines virales, Simulation de docking moléculaire, Structure moléculaire.
English descriptors
- KwdEn :
- Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Catalytic Domain, Cysteine Endopeptidases (chemistry), Cysteine Proteinase Inhibitors (chemical synthesis), Cysteine Proteinase Inhibitors (chemistry), Cysteine Proteinase Inhibitors (pharmacology), Isoquinolines (chemical synthesis), Isoquinolines (chemistry), Isoquinolines (pharmacology), Molecular Docking Simulation, Molecular Structure, SARS Virus (enzymology), Viral Proteins (antagonists & inhibitors), Viral Proteins (chemistry).
- MESH :
- chemical , antagonists & inhibitors : Viral Proteins.
- chemical , chemical synthesis : Antiviral Agents, Cysteine Proteinase Inhibitors, Isoquinolines.
- chemical , chemistry : Antiviral Agents, Cysteine Endopeptidases, Cysteine Proteinase Inhibitors, Isoquinolines, Viral Proteins.
- chemical , pharmacology : Antiviral Agents, Cysteine Proteinase Inhibitors, Isoquinolines.
- enzymology : SARS Virus.
- Catalytic Domain, Molecular Docking Simulation, Molecular Structure.
Abstract
A non-prime site substituent and warheads combined with a decahydroisoquinolin scaffold was evaluated as a novel inhibitor for severe acute respiratory syndrome (SARS) chymotrypsin-like protease (3CLpro). The decahydroisoquinolin scaffold has been demonstrated to be an effective hydrophobic center to interact with S2 site of SARS 3CLpro, but the lack of interactions at S3 to S4 site is thought to be a major reason for the moderate inhibitory activity. In this study, the effects of an additional non-prime site substituent on the scaffold as well as effects of several warheads are evaluated. For the introduction of a desired non-prime site substituent, amino functionality was introduced on the decahydroisoquinolin scaffold, and the scaffold was constructed by Pd(II) catalyzed diastereoselective ring formation. The synthesized decahydroisoquinolin inhibitors showed about 2.4 times potent inhibitory activities for SARS 3CLpro when combined with a non-prime site substituent. The present results indicated not only the expected additional interactions with the SARS 3CLpro but also the possibility of new inhibitors containing a fused-ring system as a hydrophobic scaffold and a new warhead such as thioacetal.
DOI: 10.1016/j.bmc.2018.12.019
PubMed: 30558861
Affiliations:
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Le document en format XML
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The decahydroisoquinolin scaffold has been demonstrated to be an effective hydrophobic center to interact with S2 site of SARS 3CL<sup>pro</sup>, but the lack of interactions at S3 to S4 site is thought to be a major reason for the moderate inhibitory activity. In this study, the effects of an additional non-prime site substituent on the scaffold as well as effects of several warheads are evaluated. For the introduction of a desired non-prime site substituent, amino functionality was introduced on the decahydroisoquinolin scaffold, and the scaffold was constructed by Pd(II) catalyzed diastereoselective ring formation. The synthesized decahydroisoquinolin inhibitors showed about 2.4 times potent inhibitory activities for SARS 3CL<sup>pro</sup> when combined with a non-prime site substituent. The present results indicated not only the expected additional interactions with the SARS 3CL<sup>pro</sup> but also the possibility of new inhibitors containing a fused-ring system as a hydrophobic scaffold and a new warhead such as thioacetal.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Ohnishi, Kouji" sort="Ohnishi, Kouji" uniqKey="Ohnishi K" first="Kouji" last="Ohnishi">Kouji Ohnishi</name></noRegion><name sortKey="Akaji, Kenichi" sort="Akaji, Kenichi" uniqKey="Akaji K" first="Kenichi" last="Akaji">Kenichi Akaji</name><name sortKey="Hattori, Yasunao" sort="Hattori, Yasunao" uniqKey="Hattori Y" first="Yasunao" last="Hattori">Yasunao Hattori</name><name sortKey="Kobayashi, Kazuya" sort="Kobayashi, Kazuya" uniqKey="Kobayashi K" first="Kazuya" last="Kobayashi">Kazuya Kobayashi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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